Analysis of the core region of HCV genome isolated from patients with chronic hepatitis C during intervals of normal ALT concentration.
J Gastroenterol
; 31(1): 140-2, 1996 Feb.
Article
em En
| MEDLINE
| ID: mdl-8808445
ABSTRACT
We determined the core region nucleotide and amino acid sequences in specimens from two patients with chronic hepatitis C during intervals of normal and elevated alanine aminotransferase (ALT) concentrations. When the ALT concentrations remained normal, the serum HCR-RNA concentration exceeded that before therapy and most of the clones that could be sequenced had a deletion or an amber mutation. The clones isolated from a HLA B44-positive patient had a mutation at amino acid 91. These results suggest that expression of the wild-type HCV core region genome may be associated with liver cell damage.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Genoma Viral
/
Hepatite C
/
Hepacivirus
/
Hepatite Crônica
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Gastroenterol
Ano de publicação:
1996
Tipo de documento:
Article