Impact of prophylactic ganciclovir on bronchoalveolar lavage lymphocyte numbers and phenotypes in murine cytomegalovirus-induced reactivation of Toxoplasma pneumonia.
J Lab Clin Med
; 128(4): 384-91, 1996 Oct.
Article
em En
| MEDLINE
| ID: mdl-8833887
ABSTRACT
In a mouse model of cytomegalovirus (CMV)-induced immunosuppression, murine CMV (MCMV) infection results in reactivation of Toxoplasma pneumonia, and prophylactic but not delayed administration of ganciclovir attenuates the severity of this pneumonia. We now report that the protection observed with ganciclovir is associated with blunting of the alterations in bronchoalveolar lavage (BAL) lymphocyte numbers and phenotypes observed in untreated mice. Specifically, prophylactic ganciclovir prevents the usual drop in BAL CD4+ lymphocytes observed in the first week after MCMV injection--that is, the period of MCMV-associated immunosuppression. Furthermore, prophylactic ganciclovir markedly blunts the usual rise in BAL T lymphocytes (CD8+ > CD4+) seen later during the peak of reactivated Toxoplasma pneumonia. These findings suggest that prophylactic ganciclovir can protect animals from virus-associated opportunistic pneumonia by attenuating virus-induced changes in BAL lymphocytes and the attendant suppression of lung immunity.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
/
4_TD
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Pneumonia
/
Ganciclovir
/
Toxoplasmose Animal
/
Infecções por Citomegalovirus
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Lab Clin Med
Ano de publicação:
1996
Tipo de documento:
Article