A second trefoil protein, ITF/hP1.B, is transcribed in human breast cancer.
Breast Cancer Res Treat
; 38(2): 145-51, 1996.
Article
em En
| MEDLINE
| ID: mdl-8861832
ABSTRACT
Trefoil proteins form a specific group of stable secreted polypeptides. They are expressed in a lot of human cancers and during inflammatory processes of the gastrointestinal tract. Recently a new human trefoil protein, ITF/hP1.B, was isolated. Until now no studies of the activity of this gene in human solid tumors exist. In our examination we show for the first time that this gene is transcribed in human breast cancer. In contrast to another trefoil protein, pS2, the expression of ITF/hP1.B is not under control of estrogen in the human breast cancer cell line MCF-7. We suggest that the gene activity of ITF/hP1.B in addition to pS2 expression may be an improved prognostic marker in human breast cancer.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biossíntese Peptídica
/
Neuropeptídeos
/
Neoplasias da Mama
/
Proteínas
/
Substâncias de Crescimento
/
Mucinas
/
Proteínas Musculares
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Breast Cancer Res Treat
Ano de publicação:
1996
Tipo de documento:
Article