Effects of aluminum chloride on normal and uremic adult male rats. Tissue distribution, brain choline acetyltransferase activity, and some biological variables.
Biol Trace Elem Res
; 54(1): 43-53, 1996 Jul.
Article
em En
| MEDLINE
| ID: mdl-8862760
ABSTRACT
Normal and uremic adult male rats were given a daily ip injection of 20 mg Al (Al chloride)/kg for 14 d. The results indicate that Al induces a significant decrease in food ingestion, weight gain, and total protein concentration in the plasma. Compared with control animals, very high increases in Al levels were found in plasma and hepatic homogenates (about 36 and 19 times, respectively). In the brain homogenates, the Al increases were lower (about 23%). The brain cholineacetyltransferase activity was reduced 10.6 and 14.9% in normal and uremic rats, respectively. The nephrectomy and the food restriction did not affect the total protein concentrations in plasma and the cerebral cholineacetyltransferase activity. Both were only found to be reduced in the rats treated by Al chloride.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adstringentes
/
Uremia
/
Cloretos
/
Compostos de Alumínio
Limite:
Animals
Idioma:
En
Revista:
Biol Trace Elem Res
Ano de publicação:
1996
Tipo de documento:
Article