Rapid down-regulation of beta-adrenergic receptors evoked by combined forced swimming test and CGP 37849--a competitive antagonist of NMDA receptors.
Pol J Pharmacol
; 47(6): 537-40, 1995.
Article
em En
| MEDLINE
| ID: mdl-8868377
ABSTRACT
The influence of CGP 37849, a competitive antagonist of NMDA, receptors and desipramine (DMI) on the density of beta-adrenergic receptors in rats exposed to the forced swimming test was investigated. CGP 37849 (10 mg/kg) and DMI (15 mg/kg), given twice to rats (24 h apart), or the forced swimming test alone failed to alter the density of beta-adrenergic receptors in the rat cortex, as tested using [3H]dihydroalprenolol ([3H]DHA). However, in rats injected with CGP 37849 (10 mg/kg) or DMI (15 mg/kg) and exposed to the forced swimming test, it was found that the density of beta-adrenergic receptors in the cortex was decreased. It was also observed that CGP 37849 used in a dose which decreased the density of beta-adrenergic receptors reduced the immobility time in a manner similar to DMI. It is concluded that CGP 37849 may evoke similar adaptive receptor changes as anti-depressant drugs which-in turn-suggests antidepressant-like properties of CGP 37849.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
/
2-Amino-5-fosfonovalerato
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Regulação para Baixo
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Receptores Adrenérgicos beta
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Receptores de N-Metil-D-Aspartato
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Antagonistas Adrenérgicos beta
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Antagonistas de Aminoácidos Excitatórios
Limite:
Animals
Idioma:
En
Revista:
Pol J Pharmacol
Ano de publicação:
1995
Tipo de documento:
Article