Thyroid-stimulating hormone responses after single administration of thyrotropin-releasing hormone and combined administration of four hypothalamic releasing hormones in beagle dogs.
Domest Anim Endocrinol
; 13(5): 465-8, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8886599
ABSTRACT
Thyrotropin (TSH) responses were determined in eight healthy male beagle dogs after a single administration of thyrotropin-releasing hormone (TRH) and the combined administration of four hypothalamic releasing hormones, i.e., corticotropin-releasing hormone, growth hormone-releasing hormone, gonadotropin-releasing hormone, and TRH. In both tests, TRH was administered in a dose of 10 micrograms/kg. Basal TSH concentrations ranged from 0.07 to 0.27 microgram/l (mean +/- SE, 0.14 +/- 0.02 microgram/l). The administration of TRH, alone or in the combined test, resulted in a prompt and significant increase in TSH with mean (+/-SE) plasma TSH peaks of 1.26 +/- 0.22 micrograms/l at 10 min and 0.85 +/- 0.17 microgram/l at 30 min, respectively. The area under the curve (0-120 min) was significantly lower in the combined test than in the single TRH test, whereas the increments were not significantly different. It is concluded that measurements of TSH responses to TRH alone and in combination with other releasing hormones can be used for the assessment of pituitary thyrotropic cell function. In the combined test, the TSH response is slightly lower than that in the single test.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tireotropina
/
Hormônios Liberadores de Hormônios Hipofisários
/
Hormônio Liberador de Tireotropina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Domest Anim Endocrinol
Ano de publicação:
1996
Tipo de documento:
Article