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Molecular analysis and polymorphism of the DLA-DQA gene.
Wagner, J L; Burnett, R C; DeRose, S A; Storb, R.
Afiliação
  • Wagner JL; Transplantation Biology Program, Fred Hutchinson Cancer Research Center, Seattle, USA.
Tissue Antigens ; 48(3): 199-204, 1996 Sep.
Article em En | MEDLINE | ID: mdl-8896179
A full-length cDNA clone and two overlapping genomic clones corresponding to the canine DQA class II gene were isolated and sequenced. Restriction mapping and sequence data allow identification and orientation of the five exons corresponding to the alpha (alpha) chain. Sequence analysis of exon 2 amplified from 17 unrelated dogs of various breeds identified seven alleles. The structure of the canine DQA gene is similar to HLA-DQA1 and other mammalian DQA genes. This study will serve as a reference for developing a typing system for the DLA-DQA gene for donor and recipient matching in the canine model for organ and bone marrow transplantation.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Antígenos de Histocompatibilidade Classe I / Antígenos HLA-DQ Limite: Animals Idioma: En Revista: Tissue Antigens Ano de publicação: 1996 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polimorfismo Genético / Antígenos de Histocompatibilidade Classe I / Antígenos HLA-DQ Limite: Animals Idioma: En Revista: Tissue Antigens Ano de publicação: 1996 Tipo de documento: Article