Gender and species differences in the metabolism of 1,3-butadiene to butadiene monoepoxide and butadiene diepoxide in rodents following low-level inhalation exposures.
Toxicology
; 113(1-3): 322-5, 1996 Oct 28.
Article
em En
| MEDLINE
| ID: mdl-8901918
ABSTRACT
Levels of butadiene monoepoxide (BDO) and butadiene diepoxide (BDO2) were compared in tissues of male Sprague-Dawley rats and male B6C3F1 mice and in tissues of male and female Sprague-Dawley rats following inhalation exposures to 62.5 ppm 1,3-butadiene (BD). In male rats, BDO2 levels were highest in blood and were present at a concentration of only 5 +/- 1 pmol/g. Following a 6-h exposure, the concentration of BDO2 in the blood, femurs, lung and fat of female rats was 3 to 7-fold that of male rats. Levels of BDO were similar in tissues of female and male rats. Generally, levels of BDO were approximately 3 to 8-fold greater in mouse tissues as compared with rat tissues following 4-h exposures to BD. In blood, 204 +/- 15 pmol/g BDO2 was detected in male mice, while in rats, blood BDO2 levels were 5 +/- 1 pmol/g. This study shows marked species differences in tissue levels of BD epoxides, particularly BDO2, in rats and mice, and is the first to show gender differences in BD metabolism.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Butadienos
/
Carcinógenos
/
Compostos de Epóxi
Aspecto:
Determinantes_sociais_saude
Limite:
Animals
Idioma:
En
Revista:
Toxicology
Ano de publicação:
1996
Tipo de documento:
Article