Synthesis and biological activity of a conformationally constrained chemotactic gamma-lactam formyl tetrapeptide.
Arzneimittelforschung
; 46(10): 964-6, 1996 Oct.
Article
em En
| MEDLINE
| ID: mdl-8931889
ABSTRACT
The synthesis and biological activity on human neutrophils of for-Met-(gamma-lactam)-Leu-Phe-OMe [fM(gamma l)LP-OMe], an analogue of the chemotactic fMLP-OMe, are reported. The tetrapeptide evidences chemotactic activity as well as superoxide anion production and lysozyme release, although with lower efficacy when compared with the parent tripeptide.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Fatores Quimiotáticos
Limite:
Humans
Idioma:
En
Revista:
Arzneimittelforschung
Ano de publicação:
1996
Tipo de documento:
Article