Response of the rat mucosal and connective tissue type mast cells to interferon-alpha.
Acta Physiol Pharmacol Ther Latinoam
; 46(1): 11-21, 1996.
Article
em En
| MEDLINE
| ID: mdl-8935487
ABSTRACT
The distribution, density and histochemical subtype of mast cells (mucosal and connective tissue) were studied in the ileum, trachea and skin of rats treated with IFN alpha (70.000 IU/kg) treated rats. Light and electron microscopic procedures were utilized. The total number of mucosal mast cells in the sections of ileum and trachea were markedly increased in the IFN-alpha treated group (ileum 31.9 +/- 2.2 cells/villuscrypt unit; trachea 10,355 +/- 264 cells/mm3). However, the number of connective tissue mast cells did not show any significant change in the skin between IFN-alpha treated (1,472 +/- 125 cells/mm3) and saline-treated (1,757 +/- 264 cells/mm3) groups. We conclude that mast cell proliferation does exist in the rat ileum and trachea but no in the skin response to IFN-alpha. We suggest that this model provides a powerful tool to study differential effects of IFN-alpha on mast cell subtypes and to identify their role in the immunoregulatory and inflammatory reactions.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Traqueia
/
Interferon-alfa
/
Íleo
/
Mastócitos
Limite:
Animals
Idioma:
En
Revista:
Acta Physiol Pharmacol Ther Latinoam
Ano de publicação:
1996
Tipo de documento:
Article