Self assertion modeled as a network repertoire of multi-determinant antibodies.
J Theor Biol
; 183(1): 55-66, 1996 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-8959110
ABSTRACT
We study repertoire selection in a network of natural antibodies that is maintained by stimulatory idiotypic interactions. The natural antibody repertoire develops in an environment of self epitopes to which the self-reactive B cell clones are completely tolerant. For the modeling formalism, we extend the shape space framework so that each antibody is represented by several randomly chosen shapes. B cell clones are generated stochastically and are removed whenever their density falls below an extinction threshold. The idiotypic interactions are governed by a log bell-shaped interaction function. The natural antibody repertoire in the model is formed by percolation the network is autonomously activated following a point stimulation. Our main conclusion is that the natural antibody repertoire organizes itself in such a way that most self epitopes are included in the repertoire. We find an over-representation of antibody determinants that are similar to self epitopes. We speculate that the network forms a "smoke screen" covering the somatic self.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vertebrados
/
Modelos Imunológicos
/
Sistema Imunitário
/
Anticorpos
/
Epitopos
Limite:
Animals
Idioma:
En
Revista:
J Theor Biol
Ano de publicação:
1996
Tipo de documento:
Article