p53 mutations and occupational exposures in a surgical series of lung cancers.
Cancer Epidemiol Biomarkers Prev
; 5(12): 997-1003, 1996 Dec.
Article
em En
| MEDLINE
| ID: mdl-8959323
ABSTRACT
p53 mutations are frequent in malignant lung tumors. Of 88 surgically treated lung cancers from cigarette smokers previously evaluated for p53 mutations, 45 tumors (51.1%) had mutations in exons 5-8 (D. G. Guinee, Jr. et al., Carcinogenesis (Lond.), 16 993-1002, 1995). We report here the examination of 13 occupational exposures and 13 high-risk occupations in relation to these p53 mutations. Two molecular abnormalities were associated with occupational exposures (a) GC-->TA transversions on the coding (nontranscribed) strand (n = 13) were associated with chromate exposure and employment in the metal industry (P < 0.05) and marginally associated with nickel exposure (P = 0.056); and (b) GC-->AT transitions at non-CpG sites (n = 9) were associated with work in the petrochemical industry (P = 0.05). No association was found between p53 mutations and gender, cigarette pack-years, tumor histology, age at diagnosis, or family history of lung cancer. Because all three chromate-exposed subjects had large cell carcinomas exhibiting G C-->TA coding-strand transversions, follow-up of a cohort with this exposure should clarify the association with the p53 gene.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma
/
Genes p53
/
Exposição Ocupacional
/
Proteína Supressora de Tumor p53
/
Mutação Puntual
/
Neoplasias Pulmonares
/
Doenças Profissionais
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Cancer Epidemiol Biomarkers Prev
Ano de publicação:
1996
Tipo de documento:
Article