Synthesis and microbiological evaluations of (N-heteroaryl) arylmethanamines and their Schiff bases.
Farmaco
; 51(10): 643-52, 1996 Oct.
Article
em En
| MEDLINE
| ID: mdl-8981754
ABSTRACT
The synthesis as well as the antimicrobial and antiviral activities of new (N-heteroaryl)arylmethanamines and their Schiff bases are reported. None of the tested compounds shown activity against Herpes simplex virus type 2 and against Gram positive and Gram negative bacteria. Weak or moderate activity on poliovirus Sabin type 1, on reverse transcriptase and against Cryptococcus neoformans was shown by some of the tested compounds. Viceversa several synthesized compounds exhibited a moderate or good activity against strains of Candida albicans, while only some of the tested compounds were found moderately active against strains of Candida sp. Instead numerous new compounds 3 or 4 were active as control against isolates of plant pathogenic fungi. The obtained results are discussed on the basis of structure-activity relationships.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Aminas
/
Anti-Infecciosos
Idioma:
En
Revista:
Farmaco
Ano de publicação:
1996
Tipo de documento:
Article