A modification of the N-terminal amino acid in the eremomycin aglycone.
J Antibiot (Tokyo)
; 49(11): 1157-61, 1996 Nov.
Article
em En
| MEDLINE
| ID: mdl-8982345
ABSTRACT
An Edman degradation of the antibiotic eremomycin aglycone produced the corresponding hexapeptide, which was aminoacylated with D-lysine, D-histidine or D-tryptophan derivatives to give new heptapeptide analogs of the eremomycin aglycone. The aminoacylation of the eremomycin aglycone produced an octapeptide analog. The substitution of D-lysine for the N-terminal N-methyl-D-leucine does not seriously affect the in vitro antibacterial properties of the eremomycin aglycone whereas the heptapeptides with the N-terminal D-tryptophan or D-histidine moieties and the octapeptide with the N-terminal D-lysine are practically devoid of the antibacterial properties.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Peptídeos Catiônicos Antimicrobianos
/
Antibacterianos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1996
Tipo de documento:
Article