Experimental nonsurgical transcervical sterilization with a custom-designed platinum microcoil.
J Vasc Interv Radiol
; 8(1 Pt 1): 113-8, 1997.
Article
em En
| MEDLINE
| ID: mdl-9025049
ABSTRACT
PURPOSE:
Investigation of a technique for nonsurgical female sterilization. MATERIALS ANDMETHODS:
A custom designed platinum microcoil with Dacron fibers was placed unilaterally into a fallopian tube and uterine horn of 10 rabbits after transcervical selective tubal catheterization with use of fluoroscopic guidance. The contralateral uterus and fallopian tube served as controls. After the rabbits were bred, pregnancy was determined by palpation and confirmed at autopsy. Postmortem histopathologic evaluation of uteri and fallopian tubes was performed.RESULTS:
Nine of the 10 rabbits became pregnant. None of the animals had embryos on the microcoil side. Nine rabbits had a total of 45 embryos on the control side. One animal failed to become pregnant on either side. The microcoil remained in good position in all 10 rabbits. There was a microcoil-associated, mild inflammatory tissue response in the uteri and fallopian tubes.CONCLUSION:
A platinum occlusion microcoil placed in a utero-tubal location has potential as a means for nonsurgical female sterilization.ABSTRACT
PIP At Milton S. Hershey Medical Center in Hershey, Pennsylvania, researchers used fluoroscopy to guide transcervical selective tubal catheterization in order to correctly insert a custom-designed platinum microcoil with Dacron fibers 1.5-6 cm into a fallopian tube and 1.5-5.5 cm into a uterine horn of 10 rabbits. The fallopian tube and uterine horn on the opposite side were the controls. The researchers sacrificed the rabbits to conduct histopathologic examination of the uteri and fallopian tubes in order to determine the presence or absence of embryos. One rabbit had no embryos on either side, even after 4 breeding attempts. Among the remaining 9 rabbits, there were no embryos on the microcoil side and 45 embryos on the control side. The position of the microcoil did not change in any rabbit. The microcoil caused a mild inflammatory tissue response in the uteri and fallopian tubes. Longer-term studies in more animals are necessary to confirm the efficacy and safety of this sterilization method as well as to determine the potential for retrievability of the microcoil and reversibility of the sterilization effect. In conclusion, a uterotubal coil may someday be a safe, effective, minimally invasive means of female sterilization.
Palavras-chave
Americas; Animals, Laboratory; Biology; Clinical Research; Developed Countries; Fallopian Tubes; Family Planning; Female Sterilization; Genitalia; Genitalia, Female; North America; Northern America; Pennsylvania; Physiology; Research Methodology; Research Report; Sterilization, Sexual; Tubal Occlusion; United States; Urogenital System; Uterine Effects; Uterus
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esterilização Tubária
/
Colo do Útero
/
Dispositivos Intrauterinos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Vasc Interv Radiol
Ano de publicação:
1997
Tipo de documento:
Article