Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues.
Gene
; 185(2): 187-93, 1997 Feb 07.
Article
em En
| MEDLINE
| ID: mdl-9055814
ABSTRACT
From a rat skin wound healing cDNA library, a clone encoding stromelysin 3 (ST3) was isolated. The predicted rat ST3 has 491 amino acids, and shows 83, 95 and 58% homology with human, mouse and Xenopus ST3, respectively. COS-1 cells transfected with this rat ST3 cDNA produced the ST3 proform, which could be converted to the mature ST3 form by co-transfection with rat furin cDNA. In addition to healing skin, the rat ST3 gene was found to be strongly expressed in normal adult uterus and ovary, and at lower levels in chemically-induced mammary tumors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Metaloendopeptidases
/
Subtilisinas
Limite:
Animals
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Gene
Ano de publicação:
1997
Tipo de documento:
Article