Indirect T-cell allorecognition: perspectives for peptide-based therapy in transplantation.
Immunol Today
; 18(2): 67-71, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9057356
ABSTRACT
Indirect allorecognition is an important component of allotransplant rejection. Although the initial indirect alloresponse is limited to a few dominant determinants on donor major histocompatibility complex (MHC) molecules, subsequent spreading to additional determinants on recipient and donor antigens is common. Gilles Benichou and colleagues discuss the mechanisms by which immunodominance is acquired or disrupted in indirect alloresponses, and examine the implications for the design of peptide-based selective immunotherapy in transplantation.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Transplante Homólogo
/
Linfócitos T
/
Imunoterapia
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immunol Today
Ano de publicação:
1997
Tipo de documento:
Article