Use of a catecholamine sensor in the control of an artificial heart system.
Int J Artif Organs
; 20(1): 37-42, 1997 Jan.
Article
em En
| MEDLINE
| ID: mdl-9062830
ABSTRACT
An electrochemical sensor system to allow real-time measurement and feedback of catecholamine concentrations was developed for use in the control of artificial hearts. Electrochemical analyses were carried out using a carbon fiber working electrode, an Ag-AgCl reference electrode, and a potentiostat. The operating parameters of the pneumatically-driven artificial heart system were altered in accordance with the algorithm for changes in the catecholamine concentration. The minimum detectable concentrations of both adrenaline and noradrenaline in a mock circulatory system using a phosphate-buffered solution were approximately 1-2 ng/ml (10(-8) mol/L). An artificial heart control system utilizing this set-up performed satisfactorily without delay, although sensor sensitivity decreased when placed in goat plasma instead of a phosphate-buffered solution, due to the adsorption of various substances such as plasma proteins onto the electrodes. This study demonstrated the future feasibility of a feedback control system for artificial hearts using catecholamine concentrations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epinefrina
/
Norepinefrina
/
Coração Artificial
Limite:
Animals
Idioma:
En
Revista:
Int J Artif Organs
Ano de publicação:
1997
Tipo de documento:
Article