[Chronic granulomatous disease (CGD): dysfunction of the neutrophil granulocyte NADPH-oxidase enzyme system]. / Krónikus granulomatózus betegség (CGD): a neutrofil granulocita NADPH-oxidáz enzimrendszerének múködésképtelensége.
Orv Hetil
; 138(7): 397-401, 1997 Feb 16.
Article
em Hu
| MEDLINE
| ID: mdl-9091840
ABSTRACT
Dysfunction of NADPH oxidase results in chronic granulomatous disease (CGD), a syndrome characterized by severe bacterial and fungal infections. Phagocytes of the patients are unable to kill ingested microorganisms which leads to the formation of granulomas and abscesses. Predominant pathogens are the catalase-positive bacteriae (Staphylococcus aureus) and some fungi (Aspergillus species). Infections of these patients should be treated by antimicrobial agents, which penetrate cells and kill pathogens inside. The aim of this study was to give a short description of the structure and function of the NADPH oxidase enzyme and to summarize the results obtained during the diagnostic of 10 patients with chronic granulomatous disease. Characterization of the disease was confirmed by mutation analyses.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Disfunção de Fagócito Bactericida
/
NADPH Oxidases
/
Doença Granulomatosa Crônica
Limite:
Humans
Idioma:
Hu
Revista:
Orv Hetil
Ano de publicação:
1997
Tipo de documento:
Article