[Effect of the nude mutation on alpha-fetoprotein synthesis and hemopoiesis in the mouse liver in the postnatal period of development]. / Vliianie mutatsii nude na sintez al'fa-fetoproteina i gempoéz v pecheni myshei v postnatal'nom periode razvitiia.
Ontogenez
; 10(5): 483-90, 1979.
Article
em Ru
| MEDLINE
| ID: mdl-91148
ABSTRACT
The dynamics of population of alpha-fetoprotein (AFP)-containing cells in the liver and the level of AFP in the blood of C3H/HeJ+/+ and thymus-less mutant C3H/HeJnu/nu mice during postnatal development was studied by means of indirect immunofluorescence and radial immunodiffusion. The content of AFP-positive hepatocytes and AFP concentration in the blood serum of C3H/HeJnu/nu mice were shown to exceed markedly those in C3H/HeJ+/+ mice beginning from the age of 2 weeks. The histological analyses has revealed the foci of hemopoiesis in the liver of adult C3H/HeJnu/nu mice, unlike in the liver of normal mice. The neonatal thymectomy of C3H/HeJ+/+ mice did not influence the parameters under study. A possible relationship between the increased AFP level and the preservation of hemopoiesis in the liver of the mice homozygous by the mutation nude is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alfa-Fetoproteínas
/
Hematopoese
/
Fígado
/
Camundongos Nus
/
Mutação
Limite:
Animals
Idioma:
Ru
Revista:
Ontogenez
Ano de publicação:
1979
Tipo de documento:
Article