Do low levels of MHPG in depressive spectrum patients normalize after successful treatment?
Neuropsychobiology
; 34(4): 188-91, 1996.
Article
em En
| MEDLINE
| ID: mdl-9121619
ABSTRACT
Patients with depressive spectrum disorder (DSD) have low levels of the norepinephrine metabolite, MHPG. This study examines what happens to the low levels of MHPG following improvement of depressive symptoms. Sixteen depressed patients with a family history consistent with DSD showed no change in MHPG after 6 weeks of treatment. This was true for both treatment responders and nonresponders. The lack of change in low levels of MHPG suggests that reduced norepinephrine turnover is a biological trait of DSD patients. Implications of this finding are discussed.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Terapia Cognitivo-Comportamental
/
Transtorno Depressivo
/
Imipramina
/
Metoxi-Hidroxifenilglicol
/
Antidepressivos Tricíclicos
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Neuropsychobiology
Ano de publicação:
1996
Tipo de documento:
Article