Neuroleptic binding to sigma receptors: possible involvement in neuroleptic-induced acute dystonia.
Biol Psychiatry
; 41(10): 1010-9, 1997 May 15.
Article
em En
| MEDLINE
| ID: mdl-9129781
ABSTRACT
Several antipsychotic drugs, belonging to various chemical classes, were compared for their affinity for the sigma, dopamine-D2, and muscarinic receptors. Many neuroleptic drugs were found to bind with high affinity to sigma 2 receptors, and the binding affinity was clearly different from that observed for dopamine-D2 receptors. The dopaminergic and muscarinic theories for the physiopathology of acute dystonia are not completely satisfactory. Since the sigma receptors were reported to play a role in the control of movement, the high affinity of some neuroleptics for these sites suggests their possible involvement in some side effects, such as drug-induced dystonia. There was a correlation between the clinical incidence of neuroleptic-induced acute dystonia and binding affinity of drugs for the sigma receptor, except for some drugs, with a lower incidence, displaying significant affinity for the cholinergic muscarinic receptor. Therefore, we conclude that the affinity for the sigma receptor might be involved in neuroleptic-induced acute dystonia, but this might be partially corrected by the intrinsic anticholinergic properties of the drug.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antipsicóticos
/
Receptores sigma
/
Discinesia Induzida por Medicamentos
Limite:
Animals
Idioma:
En
Revista:
Biol Psychiatry
Ano de publicação:
1997
Tipo de documento:
Article