Effect of long-term treatment with salmeterol on asthma control: a double blind, randomised crossover study.
BMJ
; 314(7092): 1441-6, 1997 May 17.
Article
em En
| MEDLINE
| ID: mdl-9167559
ABSTRACT
OBJECTIVES:
To determine the effect of adding salmeterol 50 micrograms twice daily for six months to current treatment in subjects with asthma who control their inhaled corticosteroid dose according to a management plan.DESIGN:
A double blind, randomised crossover study.SETTING:
Nottingham.SUBJECTS:
101 subjects with mild or moderate asthma taking at least 200 micrograms twice daily of beclomethasone dipropionate or budesonide.INTERVENTIONS:
Salmeterol 50 micrograms twice daily and placebo for six months each, with a one month washout. Subjects adjusted inhaled steroid dose according to guidelines. MAIN OUTCOMEMEASURE:
Reduction in inhaled steroid use, exacerbations of asthma, and use of oral steroids.RESULTS:
Data were available for 87 subjects. When compared with placebo salmeterol treatment was associated with a 17% reduction in inhaled steroid use (95% confidence interval 12% to 22%) with no significant difference in the number of subjects who had an exacerbation (placebo 25%, salmeterol 16%) or use of oral steroids. For secondary end points salmeterol treatment was associated with higher morning and evening peak expiratory flow and forced expiratory volume in one second; a reduction in symptoms, bronchodilator use and airway responsiveness to methacholine; and no effect on serum potassium concentration, 24 hour heart rate, or the final forced expiratory volume in one second achieved during a salbutamol dose-response study.CONCLUSIONS:
In subjects who adjusted their inhaled steroid treatment according to guidelines the addition of salmeterol 50 micrograms twice daily was associated with a reduction in inhaled steroid use and improved lung function and symptom control.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Broncodilatadores
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Agonistas Adrenérgicos beta
/
Albuterol
Tipo de estudo:
Clinical_trials
/
Guideline
Limite:
Adult
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
BMJ
Ano de publicação:
1997
Tipo de documento:
Article