Number, distribution and neuropeptide content of rat knee joint afferents.
J Anat
; 190 ( Pt 4): 515-22, 1997 May.
Article
em En
| MEDLINE
| ID: mdl-9183675
ABSTRACT
Retrograde tracing with Fluoro-Gold was used to identify the complete population of knee joint afferents in the lumbar dorsal root ganglia of adult female Wistar rats. There was an average of 581 +/- 31 (mean +/- S.D.) afferents supplying each joint. These were found distributed from L1 to L5 with the great majority localised in the L3 and L4 ganglia. Electron microscopy of the posterior articular nerve of the knee revealed an average of 103 +/- 15 (mean +/- S.D.) myelinated and 513 +/- 39 unmyelinated axonal profiles. Since about 50-60% of the unmyelinated profiles would be expected to be sympathetic efferents, these numbers are consistent with the numbers of afferents found by Fluoro-Gold retrograde tracing and suggest that the posterior articular nerve contains about 50% of the total number of knee joint afferents in the rat. Immunohistochemistry revealed that an average of 10% of identified joint afferents expressed substance P-like immunoreactivity and that 33% expressed calcitonin gene-related peptide-like immunoreactivity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estilbamidinas
/
Neuropeptídeos
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Gânglios Espinais
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Articulações
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Neurônios Aferentes
Limite:
Animals
Idioma:
En
Revista:
J Anat
Ano de publicação:
1997
Tipo de documento:
Article