Multistage regulation of Th1-type immune responses by the transcription factor IRF-1.
Immunity
; 6(6): 673-9, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9208840
ABSTRACT
Eradication of a given pathogen is dependent on the selective differentiation of T helper (Th) cells into Th1 or Th2 types. We show here that T cells from mice lacking the transcription factor IRF-1 fail to mount Th1 responses and instead exclusively undergo Th2 differentiation in vitro. Compromised Th1 differentiation is found to be associated with defects in multiple cell types, namely impaired production of interleukin-12 by macrophages, hyporesponsiveness of CD4+ T cells to interleukin-12, and defective development of natural killer cells. These results indicate the involvement of IRF-1 in multiple stages of the Th1 limb of the immune response.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Fatores de Transcrição
/
Células Th1
/
Proteínas de Ligação a DNA
Limite:
Animals
Idioma:
En
Revista:
Immunity
Ano de publicação:
1997
Tipo de documento:
Article