Quinoxaline chemistry. Part 7. 2-[aminobenzoates]- and 2-[aminobenzoylglutamate]-quinoxalines as classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity.
Farmaco
; 52(3): 157-66, 1997 Mar.
Article
em En
| MEDLINE
| ID: mdl-9212450
ABSTRACT
Thirty-three quinoxalines bearing an aminobenzoyl or aminobenzoylglutamate group on position 2 and various substituents on position 3,6,7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10(-5) and 10(-4) Molar concentrations. Interesting selectivities were also recorded between 10(-8) and 10(-6) M. Among the series examined one compound (29) which was the most active also exhibited both in vitro anti-HIV protection and antifungal activity while in other two (31, 37) the antifungal activity was prevailing.
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Coleções:
01-internacional
Contexto em Saúde:
4_TD
Base de dados:
MEDLINE
Assunto principal:
Quinoxalinas
/
Fármacos Anti-HIV
/
Antagonistas do Ácido Fólico
/
Glutamatos
/
Aminobenzoatos
/
Antifúngicos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Farmaco
Ano de publicação:
1997
Tipo de documento:
Article