Conflicting objectives in chemotherapy with drug resistance.
Bull Math Biol
; 59(4): 707-24, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9214850
ABSTRACT
A system of differential equations for the control of tumor cells growth in a cycle nonspecific chemotherapy is presented. Spontaneously acquired drug resistance is accounted for, as well as the evolution in time of normal cells. In addition, optimization of conflicting objectives forms the aim of the chemotherapeutic treatment. For general cell growth, some results are given, whereas for the special case of Malthusian (exponential) growth of tumor cells and rather general growth rate for normal cells, the optimal strategy is worked out. The latter, from the clinical standpoint, corresponds to maximum drug concentration throughout the treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Matemática
/
Neoplasias
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Bull Math Biol
Ano de publicação:
1997
Tipo de documento:
Article