Pathobiology of lipopolysaccharide.
J Toxicol Environ Health
; 51(5): 415-35, 1997 Aug 08.
Article
em En
| MEDLINE
| ID: mdl-9233377
ABSTRACT
Lipopolysaccharide is a component of the gram-negative bacterial cell wall that is responsible for 25,000-50,000 deaths in the United States each year. The sequelae of gram-negative infection and septicemia leading to death include fever, hypotension with inadequate tissue perfusion, and disseminated intravascular coagulation. It is clear that different cell types respond differently to lipopolysaccharide. Furthermore, various autacoids and cytokines are released that can affect cellular function even in cell types that do not recognize lipopolysaccharide. Despite advances made in the etiology of septic shock and organ failure, therapy is still for the most part supportive and largely ineffective. The aim of this review is to summarize the current understanding of the role of lipopolysaccharide in the development of septicemia by examining signal transduction and therapeutic approaches.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Salmonella typhimurium
/
Proteínas de Fase Aguda
/
Glicoproteínas de Membrana
/
Lipopolissacarídeos
/
Escherichia coli
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Toxicol Environ Health
Ano de publicação:
1997
Tipo de documento:
Article