A low dose of streptozotocin prevents kainic acid-induced seizures and lethal effects in the rat.
Clin Exp Pharmacol Physiol
; 24(7): 503-5, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9248668
ABSTRACT
1. The effect of streptozotocin (STZ), a nitric oxide (NO) donor, on kainic acid (KA)-induced neurotoxicity was examined in Sprague-Dawley rats. 2. The administration of KA (8 mg/kg, i.p.) produced significant neurotoxicity accompanied with increased immunoreactivity for Fos-related antigen in the rat hippocampus. 3. Pretreatment with STZ (15 mg/kg, i.m.) significantly blocked the neurotoxicity induced by KA. 4. Thus, the neuroprotective effect of STZ may, at least in part, reflect the role of NO in inhibiting seizures.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Estreptozocina
/
Agonistas de Aminoácidos Excitatórios
/
Ácido Caínico
Limite:
Animals
Idioma:
En
Revista:
Clin Exp Pharmacol Physiol
Ano de publicação:
1997
Tipo de documento:
Article