High-performance liquid chromatographic analysis of methadone hydrochloride oral solution.
J Pharm Sci
; 66(12): 1749-51, 1977 Dec.
Article
em En
| MEDLINE
| ID: mdl-925941
ABSTRACT
A direct and rapid high-performance liquid chromatographic assay for methadone hydrochloride in a flavored oral solution dosage form is described. A syrup sample, one part diluted with three parts of water, is introduced onto a column packed with octadecylsilane bonded on 10 micrometer porous silica gel (reversed phase). A formic acid-ammonium formate-buffered mobile phase is linear programmed with acetonitrile. The absorbance is monitored continuously at 280 or 254 nm, using a flow-through, UV, double-beam photometer. An aqueous methadone hydrochloride solution is used for external standardization. The relative standard deviation was not more than 1.0%. Drug recovery from a syrup base was better than 99.8%.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metadona
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
1977
Tipo de documento:
Article