Modulation of pharmacological profile of diphenylethane (lefetamine-type) derivatives.
Arzneimittelforschung
; 47(7): 803-9, 1997 Jul.
Article
em En
| MEDLINE
| ID: mdl-9272235
ABSTRACT
With the aim to split the pharmacological properties of lefetamine (CAS 14148-99-3), some structural modifications of this compound have been studied. The basic group of lefetamine has been shifted from the alkyl chain to the vicinal phenyl ring and the N-substitution has been changed. The dimethylaminomethyl derivatives and chiefly the o-morpholinometyhl exhibited a strong anti-visceral chemical antinociception activity stripped of thermal antinociception properties and physical dependence liability. Furthermore, through the introduction of a diethylaminomethyl group in the lefetamine structure some derivatives were selected exhibiting besided a significant increase in the anti-visceral chemical antinociception activity, remarkable local anesthetic properties.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenetilaminas
/
Analgésicos não Narcóticos
/
Anestésicos Locais
Limite:
Animals
Idioma:
En
Revista:
Arzneimittelforschung
Ano de publicação:
1997
Tipo de documento:
Article