The histamine releasers crotamine, protamine and compound 48/80 activate specific proteases and phospholipases A2.
Biochem Mol Biol Int
; 42(6): 1171-7, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9305535
ABSTRACT
Crotamine, a basic, myonecrotic, histamine-releasing neurotoxin, was isolated from Crotalus durissus terrificus venom. Carboxypeptidase A was shown to be activated by crotamine when acting upon N-carbobenzoxyglycil-L-phenylalanine. However the activity of carboxypeptidase B upon the substrate hippuryl-L-arginine was not enhanced by this toxin. Teh basic histamine releasers protamine and compound 48/80 also activated carboxypeptidase A. These three agents activated both alpha-chymotrypsin when acting upon acetyl-L-tyrosine ethyl ester and also five snake venom phospholipase-like myotoxins acting upon egg yolk phosphatidylcholine. These findings suggest that the action of these agents during histamine release may involve the participation of specific intermediary hydrolases which, upon activation, would enhance their cytolytic effects on the sequence of events which lead to granule extrusion and histamine release from mast cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfolipases A
/
Protaminas
/
P-Metoxi-N-metilfenetilamina
/
Venenos de Crotalídeos
/
Liberação de Histamina
Idioma:
En
Revista:
Biochem Mol Biol Int
Ano de publicação:
1997
Tipo de documento:
Article