Infection of a human retinal pigment epithelial cell line with human herpesvirus 6 variant A.
J Med Virol
; 53(2): 105-10, 1997 Oct.
Article
em En
| MEDLINE
| ID: mdl-9334920
ABSTRACT
A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 cells to HHV-6A induced the formation of multinucleated giant cells, which was suppressed by an inhibitor of viral DNA synthesis. In the giant cells, herpesvirus nucleocapsids were demonstrated by electron microscopy and the viral glycoprotein B was detected by immunofluorescence assay. These results indicate that K-1034 cells are susceptible to HHV-6A and suggest that HHV-6A has an ability to directly destroy epithelial cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epitélio Pigmentado Ocular
/
Herpesvirus Humano 6
/
Células Epiteliais
Limite:
Humans
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
1997
Tipo de documento:
Article