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Beta3-adrenoceptors mediate relaxation of guinea pig taenia caecum by BRL37344A and BRL35135A.
Koike, K; Takayanagi, I; Ichino, T; Koshikawa, H; Nagatomo, T.
Afiliação
  • Koike K; Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences, Funabashi, Chiba, Japan.
Eur J Pharmacol ; 334(2-3): 217-21, 1997 Sep 10.
Article em En | MEDLINE | ID: mdl-9369351
ABSTRACT
Beta-adrenoceptor-mediated relaxation of guinea pig taenia caecum was investigated by studying the effects of the beta3-adrenoceptor agonists, BRL37344A [(R*,R*)-(+/-)-4-[2'-[2-hydroxy-2-(3-chlorophenyl) ethylamino] propyl] phenoxyacetic acid sodium salt sesquihydrate] and BRL35135A [(R*,R*)-(+/-)-methyl-4-[2-[2-hydroxy-2-(3-chlorophenyl) ethylamine] propyl] phenoxyacetate hydrobromide]. BRL37344A and BRL35135A caused dose-dependent relaxation of the guinea pig taenia caecum. The concentration-response curves for BRL37344A and BRL35135A were unaffected by propranolol, ICI118551 [erythro-1-(7-methylindan-4-yloxy)-3-(isopropylamine)-but an-2-ol], atenolol, butoxamine, prazosin, yohimbine and phentolamine. Bupranolol produced shifts of the concentration-response curves for BRL37344A and BRL35135A. Schild regression analyses carried out for bupranolol against BRL37344A and BRL35135A gave pA2 values of 5.79 and 5.84, respectively. These results suggest that the relaxant response to BRL37344A and BRL35135A of the guinea pig taenia caecum is mediated by beta3-adrenoceptors.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenetilaminas / Ceco / Receptores Adrenérgicos beta / Agonistas Adrenérgicos beta / Etanolaminas / Músculo Liso Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 1997 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenetilaminas / Ceco / Receptores Adrenérgicos beta / Agonistas Adrenérgicos beta / Etanolaminas / Músculo Liso Limite: Animals Idioma: En Revista: Eur J Pharmacol Ano de publicação: 1997 Tipo de documento: Article