Effects of gamma-butyric acid on the release of thyrotropin-releasing hormone from the rat retina in vitro.
Horm Metab Res
; 29(9): 427-9, 1997 Sep.
Article
em En
| MEDLINE
| ID: mdl-9370109
ABSTRACT
Effects of gamma-butyric acid (GABA) on the release of thyrotropin-releasing hormone (TRH) from the rat retina in vitro were studied. The rat retina was incubated in medium 199 (pH 7.4) with 1.0 mg/ml of bacitracin and 100 micrograms/ml of ascorbic acid (medium). The amount of TRH release into the medium was measured by radioimmunoassay. The TRH release from the rat retina was inhibited significantly in a dose-related manner with the addition of GABA, but not with bicuculline. The inhibitory effect of GABA on TRH release from the retina was blocked by adding bicuculline to the medium. The findings suggest that the GABAergic system inhibits TRH release from the rat retina in vitro.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Hormônio Liberador de Tireotropina
/
Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
En
Revista:
Horm Metab Res
Ano de publicação:
1997
Tipo de documento:
Article