Chronic gestational cocaine treatment decreases oxytocin levels in the medial preoptic area, ventral tegmental area and hippocampus in Sprague-Dawley rats.
Neuropeptides
; 31(5): 439-43, 1997 Oct.
Article
em En
| MEDLINE
| ID: mdl-9413020
ABSTRACT
We examined the effects of gestational cocaine treatment on oxytocin levels in the whole hippocampus (HIP), ventral tegmental area (VTA), medial preoptic area (MPOA) and amygdala (AMY) in rat dams on postpartum days (PPDs) 1 and 2. Cocaine treatment significantly reduced oxytocin levels in the MPOA within 12-16 h of delivery (PPD 1), but had no significant effect on the other brain areas. Oxytocin was significantly reduced in the HIP and VTA but not in the AMY or MPOA on PPD 2. These data provide the first evidence for the reduction of oxytocin levels in the VTA, HIP and MPOA as a result of gestational cocaine treatment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Prenhez
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Ocitocina
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Cocaína
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Inibidores da Captação de Dopamina
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Neuropeptides
Ano de publicação:
1997
Tipo de documento:
Article