Multilocus quantitative trait analysis using the multipoint identity-by-descent method.
Genet Epidemiol
; 14(6): 839-44, 1997.
Article
em En
| MEDLINE
| ID: mdl-9433587
ABSTRACT
The multipoint identity-by-descent method (MIM) was extended to test for evidence of quantitative trait loci in two independent genetic regions. This method is a fast and feasible implementation of a multiple-marker, two-region linkage analysis for quantitative traits. It tests for significant evidence of quantitative trait loci (QTL) in neither, one or both genetic regions tested, and could be extended to an arbitrary number of independent genetic regions. A two-stage analysis was used for the nuclear family data from GAW10. Initially, an analysis of the genomic search was carried out using single-region MIM, with sets of six adjacent markers. Chromosomal regions that showed some evidence of linkage were identified and used in a two-region MIM analysis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Simulação por Computador
/
Marcadores Genéticos
/
Característica Quantitativa Herdável
/
Ligação Genética
/
Modelos Genéticos
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Genet Epidemiol
Ano de publicação:
1997
Tipo de documento:
Article