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Mitochondrial control-region sequence variation in aboriginal Australians.
van Holst Pellekaan, S; Frommer, M; Sved, J; Boettcher, B.
Afiliação
  • van Holst Pellekaan S; School of Biological Sciences, University of Sydney, Sydney, NSW 2006, Australia. svanhols@mallett.nursing.usyd.edu.au
Am J Hum Genet ; 62(2): 435-49, 1998 Feb.
Article em En | MEDLINE | ID: mdl-9463317
The mitochondrial D-loop hypervariable segment 1 (mt HVS1) between nucleotides 15997 and 16377 has been examined in aboriginal Australian people from the Darling River region of New South Wales (riverine) and from Yuendumu in central Australia (desert). Forty-seven unique HVS1 types were identified, varying at 49 nucleotide positions. Pairwise analysis by calculation of BEPPI (between population proportion index) reveals statistically significant structure in the populations, although some identical HVS1 types are seen in the two contrasting regions. mt HVS1 types may reflect more-ancient distributions than do linguistic diversity and other culturally distinguishing attributes. Comparison with sequences from five published global studies reveals that these Australians demonstrate greatest divergence from some Africans, least from Papua New Guinea highlanders, and only slightly more from some Pacific groups (Indonesian, Asian, Samoan, and coastal Papua New Guinea), although the HVS1 types vary at different nucleotide sites. Construction of a median network, displaying three main groups, suggests that several hypervariable nucleotide sites within the HVS1 are likely to have undergone mutation independently, making phylogenetic comparison with global samples by conventional methods difficult. Specific nucleotide-site variants are major separators in median networks constructed from Australian HVS1 types alone and for one global selection. The distribution of these, requiring extended study, suggests that they may be signatures of different groups of prehistoric colonizers into Australia, for which the time of colonization remains elusive.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Variação Genética / DNA Mitocondrial / Havaiano Nativo ou Outro Ilhéu do Pacífico Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: Oceania Idioma: En Revista: Am J Hum Genet Ano de publicação: 1998 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Filogenia / Variação Genética / DNA Mitocondrial / Havaiano Nativo ou Outro Ilhéu do Pacífico Tipo de estudo: Prognostic_studies Limite: Humans País/Região como assunto: Oceania Idioma: En Revista: Am J Hum Genet Ano de publicação: 1998 Tipo de documento: Article