Xenopus cadherin-11 (Xcadherin-11) expression requires the Wg/Wnt signal.
Mech Dev
; 72(1-2): 101-13, 1998 Mar.
Article
em En
| MEDLINE
| ID: mdl-9533956
ABSTRACT
In this study we describe the isolation of Xcadherin-11, the Xenopus homologue to the mesenchymal cadherin-11. Similar to epithelial and neural cadherins, overexpression of Xcadherin-11 led to posteriorised phenotypes due to inhibition of convergent extension movement. Because zygotic expression of Xcadherin-11 starts with gastrulation, we analysed the ability of different growth factors involved in mesoderm differentiation to induce the expression of Xcadherin-11. Using the animal cap assay, we demonstrated that Xcadherin-11 is activated by Xwnt-8 or beta-catenin, but repressed by BMP-4. Activin did not induce Xcadherin-11 but its synergistic function was required for the Xwnt-8/beta-catenin-mediated activation of Xcadherin-11. Because Xcadherin-11 and Xenopus E- and N-cadherin are differentially regulated by growth factors in the Xenopus animal cap, our results also reveal that this assay provides a helpful model system to elucidate the molecular control mechanism of epithelial-mesenchymal conversion.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caderinas
/
Transativadores
/
Proteínas Proto-Oncogênicas
/
Proteínas de Peixe-Zebra
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Mech Dev
Ano de publicação:
1998
Tipo de documento:
Article