Group A streptococcal Vir types are M-protein gene (emm) sequence type specific.
J Clin Microbiol
; 36(4): 902-7, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9542906
The M-protein genes (emm genes) of 103 separate impetiginous Streptococcus pyogenes isolates were sequenced and the sequence types were compared to the types obtained by Vir typing. Vir typing is based on restriction fragment length polymorphism (RFLP) analysis of a 4- to 7-kb pathogenicity island encoding emm and other virulence genes. By using both HaeIII and HinfI to generate RFLP profiles, complete concordance between Vir type and emm sequence type was found. Comparison of the emm sequences with those in GenBank revealed new sequence types sharing less than 90% identity with known types. Diversity in the emm sequence was generated by corrected frameshift mutations, point mutations, and small in-frame mutations.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptococcus pyogenes
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Proteínas da Membrana Bacteriana Externa
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Proteínas de Bactérias
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Proteínas de Transporte
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Fatores de Virulência
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Antígenos de Bactérias
Idioma:
En
Revista:
J Clin Microbiol
Ano de publicação:
1998
Tipo de documento:
Article