Localization of monoclonal antibody CC49 in colonic metastasis from renal cell carcinoma.
Eur J Surg Oncol
; 24(2): 149-51, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9591035
ABSTRACT
We report a rare case of solitary metastasis from renal cell carcinoma which manifested as a primary colonic tumour 5 years after nephrectomy. A monoclonal antibody CC49 (anti-TAG-72 antibody), used in Radioimmunoguided Surgery, was found to localize in the tumour. Pathological examination revealed metastasis of renal cell carcinoma in the colon. Immunohistochemistry with CC49 showed moderate staining of the colonic mucosa around the metastasis with no reaction in the tumour itself. Based on this case and other published studies, we conclude that TAG-72, the antigen manifested in many adenocarcinomas, can be up-regulated and expressed in normal colonic mucosa adjacent to another tumour as a result of stimulations, such as cytokine release, in response to this tumour.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
/
Neoplasias do Colo
/
Neoplasias Renais
/
Anticorpos Monoclonais
/
Anticorpos Antineoplásicos
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Female
/
Humans
Idioma:
En
Revista:
Eur J Surg Oncol
Ano de publicação:
1998
Tipo de documento:
Article