Nebulized budesonide and oral dexamethasone for treatment of croup: a randomized controlled trial.
JAMA
; 279(20): 1629-32, 1998 May 27.
Article
em En
| MEDLINE
| ID: mdl-9613912
ABSTRACT
CONTEXT The effectiveness of glucocorticoids for patients with croup is well established but it remains uncertain which glucocorticoid regimen is most effective. OBJECTIVE:
To determine the effectiveness of 3 glucocorticoid regimens in patients with croup.DESIGN:
Randomized controlled trial with parallel design.SETTING:
Emergency departments of 2 Canadian pediatric tertiary care hospitals.PARTICIPANTS:
Children with a clinical syndrome consistent with croup, aged 3 months to 5 years, with a croup score of 2 or greater following at least 15 minutes of mist therapy.INTERVENTIONS:
Oral dexamethasone, 0.6 mg/kg, and nebulized placebo; oral placebo and nebulized budesonide, 2 mg; or oral dexamethasone, 0.6 mg/kg, and nebulized budesonide, 2 mg. MAIN OUTCOMEMEASURES:
Westley croup score (primary outcome), hospital admission rates, time spent in the emergency department, return visits to the emergency department, or ongoing symptoms at 1 week.RESULTS:
The mean change in the croup score from baseline to the final study assessment was -2.3 (95% confidence interval [CI], -2.6 to -2.0) in the budesonide group (n = 65), -2.4 (95% CI, -2.6 to -2.2) in the dexamethasone group (n = 69), and -2.4 (95% CI, -2.7 to -2.1) in the budesonide and dexamethasone group (n = 64, P = .70).CONCLUSIONS:
Based on the similar outcomes in the 3 groups, oral dexamethasone is the preferred intervention because of its ease of administration, lower cost, and more widespread availability.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Dexametasona
/
Crupe
/
Budesonida
/
Glucocorticoides
Tipo de estudo:
Clinical_trials
Limite:
Child, preschool
/
Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
JAMA
Ano de publicação:
1998
Tipo de documento:
Article