Pulsed methylprednisolone induces a reversible impairment of memory in patients with relapsing-remitting multiple sclerosis.
Acta Neurol Scand
; 97(6): 366-9, 1998 Jun.
Article
em En
| MEDLINE
| ID: mdl-9669468
ABSTRACT
OBJECTIVE:
Chronic administration of corticosteroids has been reported to selectively impair explicit memory in systemic diseases without central nervous system involvement. Our aim was to verify that a short course of pulsed intravenous methylprednisolone (IVMP) administered for the treatment of a relapse impairs cognitive functions in relapsing-remitting multiple sclerosis (RRMS) patients and to determine whether this impairment is reversible. MATERIAL ANDMETHODS:
Neuropsychological evaluations were made before the start of treatment, and 7 and 60 days after the end of treatment in 14 RRMS patients. The neuropsychological battery was also administered to 12 controls matched for age, sex and years of education.RESULTS:
RRMS patients performed worse than the controls at their baseline evaluation for a variety of neuropsychological tasks. IVMP administration induced a selective impairment of explicit memory which completely recovered 60 days after treatment.CONCLUSIONS:
In RRMS patients, IVMP induces a selective and reversible impairment of explicit memory.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Metilprednisolona
/
Transtornos da Memória
/
Anti-Inflamatórios
/
Esclerose Múltipla
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta Neurol Scand
Ano de publicação:
1998
Tipo de documento:
Article