Levels of inhibitors of tumor necrosis factor alpha and interleukin 1beta in urine and sera of patients with urosepsis.
Infect Immun
; 66(8): 3527-34, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9673230
ABSTRACT
The antiinflammatory cytokine response during urosepsis was determined by measurement of concentrations of soluble tumor necrosis factor receptor (sTNFR) types I and II, interleukin 1 receptor antagonist (IL-1ra), soluble IL-1 receptor type II (sIL-1RII), and interleukin 10 in sera and urine of 30 patients with culture-proven urinary tract infections before and 4, 24, 48, and 72 h after initiation of antibiotic therapy and in 20 healthy individuals. In serum, the levels of sTNFR types I and II, IL-1ra, and IL-10 were higher in patients than in controls. In urine, only sTNFR type I and II levels were elevated in patients. The ratios of concentrations of both types of sTNFR in urine to concentrations in serum were higher in patients than in controls. These findings indicate that during urosepsis, the antiinflammatory cytokine response is generated predominantly at the systemic level.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
Base de dados:
MEDLINE
Assunto principal:
Infecções por Pseudomonas
/
Piúria
/
Interleucina-1
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Fator de Necrose Tumoral alfa
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Bacteriemia
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Infecções por Escherichia coli
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Infect Immun
Ano de publicação:
1998
Tipo de documento:
Article