NF279: a novel potent and selective antagonist of P2X receptor-mediated responses.
Eur J Pharmacol
; 350(1): R5-6, 1998 May 29.
Article
em En
| MEDLINE
| ID: mdl-9683026
8,8'-(Carbonylbis(imino-4, 1 -phenylenecarbonylimino-4,1-phenylenecarbonylimino))bis(1,3, 5-naphthalenetrisulfonic acid) (NF279) antagonized P2X receptor-mediated contractions in rat vas deferens, evoked by alpha,beta-methylene ATP (10 microM; pIC50=5.71) without affecting responses mediated via alpha1A-adrenoceptors, adenosine A1 and A2B receptors, histamine H1, muscarinic M3 and nicotinic receptors. The low inhibitory potency of NF279 on P2Y receptors in guinea-pig taenia coli (pA2=4.10) and at ecto-nucleotidases in folliculated Xenopus laevis oocytes (IC50 > 100 microM) indicates that NF279 is a novel specific and selective P2X receptor antagonist.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Suramina
/
Antagonistas do Receptor Purinérgico P2
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1998
Tipo de documento:
Article