Evolution of the apolipoprotein E receptor 2 gene by exon loss.
J Biochem
; 124(2): 451-6, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9685741
ABSTRACT
The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by "exon shuffling." Analysis of apoER2 transcripts in several species reveals a lost repeat in the ligand-binding domain of primate apoER2. A pseudo-exon found in the primate apoER2 genes corresponds to the lost repeat but contains a crucial deletion that leads to a translational frameshift. The pseudo-exon sequence in primary transcripts of the human apoER2 gene is shown to be abolished by exon skipping due to two nucleotide substitutions at the 5'-splice donor adjacent to the pseudo-exon. These data suggest the occurrence of exon loss in the evolution of the primate apoER2 gene.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Éxons
/
Deleção de Genes
/
Receptores de Lipoproteínas
/
Evolução Molecular
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Biochem
Ano de publicação:
1998
Tipo de documento:
Article