Pre or post-operative medical treatment with nafarelin in stage III-IV endometriosis: a French multicenter study.
Eur J Obstet Gynecol Reprod Biol
; 79(2): 145-8, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9720832
ABSTRACT
OBJECTIVES:
To determine the effectiveness of a 6-month course of nafarelin in the treatment of stage III-IV endometriosis and to determine if pre-operative use of nafarelin facilitates surgery.DESIGN:
Prospective, multicenter, clinical trial.SETTING:
Eight university hospitals and two private practice institutions in France. PATIENTS Fifty-five patients with stage III and IV endometriosis. Two were excluded.INTERVENTIONS:
The severity of endometriosis was assessed at the time of laparoscopy and patients were randomized to have either laparosopic surgery at that time following 6 months of nafarelin therapy (n=28), or laparoscopic surgery following 6 months of nafarelin therapy (n=25). All had 200 microg intranasal nafarelin twice a day for 6 months and a second look laparoscopy. MAIN OUTCOMEMEASURE:
Clinical efficacy, tolerance to the treatment.RESULTS:
Efficacy and tolerance to the treatment were the same in both groups. AFS scores compared on both laparoscopies were significantly better if nafarelin was given prior to surgery (P=0.007).CONCLUSIONS:
This preliminary study shows that in cases of combined medico-surgical treatment for stage III-IV endometriosis, preoperative medical treatment with GnRH-a gives a better AFS score improvement, but no conclusion was possible whether preoperative treatment facilitates surgery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nafarelina
/
Endometriose
/
Hormônios
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
Ano de publicação:
1998
Tipo de documento:
Article