Design of in vitro studies to predict in vivo inhibitory drug-drug interactions.
Pharmacol Res
; 38(2): 81-8, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9721592
ABSTRACT
In vitro studies offer great potential for achieving helpful information for predicting clinical interactions between concomitantly administered drugs. Since the metabolism of drugs usually involves several pathways, the enzyme or CYP isozymes known to contribute to the metabolism of the majority of therapeutic drugs should be preferentially studied. To make corrective intervention in the stages of drug discovery and to improve the process of drug development, an early investigation of potential inhibitory drug-drug interactions is required.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
/
Alternativas aos Testes com Animais
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Pharmacol Res
Ano de publicação:
1998
Tipo de documento:
Article