HMG-17, a chromosomal non-histone protein, shows developmental regulation during organogenesis.
Int J Dev Biol
; 42(6): 775-82, 1998 Sep.
Article
em En
| MEDLINE
| ID: mdl-9727833
ABSTRACT
We used the differential hybridization technique for isolating developmentally regulated genes from the mouse metanephric kidney. In this screening, we identified the cDNA encoding high-mobility-group protein 17 (HMG-17), a chromosomal non-histone protein which modulates the conformation of transcriptionally active chromatin. Using Northern blot analysis, the HMG-17 mRNA was strongly expressed during embryogenesis and downregulated in various adult murine organs. At the histological level, the transcript localized to differentiating tissue regions and was apparently downregulated in mature structures indicating that HMG-17 expression is linked to cell differentiation. HMG-17 can thus be regarded as a general marker for tissues or cells undergoing differentiation during organogenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Grupo de Alta Mobilidade
/
Regulação da Expressão Gênica no Desenvolvimento
/
Rim
Limite:
Animals
Idioma:
En
Revista:
Int J Dev Biol
Ano de publicação:
1998
Tipo de documento:
Article