Sub-MICs of sanfetrinem promote the interaction of human polymorphonuclear granulocytes with a multiply resistant strain of Klebsiella pneumoniae.
J Antimicrob Chemother
; 42(2): 249-52, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9738845
ABSTRACT
The effect of sanfetrinem, a member of a new class of antibiotics, upon the in-vitro interaction between human polymorphonuclear granulocytes (PMNs) and a multiply resistant strain of Klebsiella pneumoniae was investigated. Sub-MICs of sanfetrinem significantly enhanced PMN phagocytosis and greatly reduced the survival of intracellular bacteria compared with antibiotic-free systems. The distinction between any effect of sanfetrinem on the klebsiellae and the phagocytes was made by exposing each of them to the drug before they were incubated together. The results indicate that sanfetrinem may have a direct positive action either on K. pneumoniae or on human granulocytes.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Klebsiella pneumoniae
/
Lactamas
/
Antibacterianos
/
Neutrófilos
Limite:
Humans
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
1998
Tipo de documento:
Article